Prkdc^m1Yum
Spontaneous Allele Detail

Summary

• Symbol: Prkdc^m1Yum
• Name: protein kinase, DNA activated, catalytic polypeptide; mutation 1, Yumie Takagi
• MGI ID: MGI:7541571
• Synonyms: Prkdc^deltaex57
• Gene: Prkdc Location: Chr16:15455730-15660099 bp, + strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Prkdc^m1Yum page

Mutation origin

• Strain of Origin: B10.S-H2^s/SgSlc

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This spontaneous mutation (TT deletion in exon 57, c.7670_7671del, GRCm39:chr16:g.15587786_15587787del) was found in an inbred B10.S-H2^s/SgSlc colony. The mutation causes a frameshift and premature stop codon (p.F2557Sfs*3). (J:341230)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkdc Mutation: 400 strains or lines available

References

• Original: J:341230 Takagi Y, et al., Characterization of novel, severely immunodeficient Prkdc(Deltaex57/Deltaex57) mice. Biochem Biophys Res Commun. 2023 Oct 20;678:193-199
• All: 1 reference(s)