Sry^em2Why
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sry^em2Why
• Name: sex determining region of Chr Y; endonuclease-mediated mutation 2, Haoyi Wang
• MGI ID: MGI:7541485
• Synonyms: Sry^fl
• Gene: Sry Location: ChrY:2662471-2663658 bp, - strand Genetic Position: ChrY, cytoband p
• Alliance: Sry^em2Why page

Mutation origin

• Strain of Origin: C57BL/6-Sry^em1Why

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag, No functional change)
• Mutation: Insertion
• Mutation details: Retargeting of Sry^em1Why inserted a loxP site 5 upstream of the exon 1 start codon generating an exon 1 floxed allele. (J:331366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sry Mutation: 51 strains or lines available

References

• Original: J:331366 Song Y, et al., Loss of circSRY reduces gammaH2AX level in germ cells and impairs mouse spermatogenesis. Life Sci Alliance. 2023 Feb;6(2)
• All: 1 reference(s)