Gt(ROSA)26Sor^{tm3(tTA,tetO-TREM2,-EGFP)Gbu}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(tTA,tetO-TREM2,-EGFP)Gbu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Guojun Bu
• MGI ID: MGI:7541478
• Synonyms: TREM2-WT
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(tTA,tetO-TREM2,-EGFP)Gbu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341604
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a floxed neomycin stop cassette, tTA, insulator, hCMV*1 promoter with a tetracycline responsive element, intron, human TREM2 tagged with 5' HA and 3' triple FLAG tags, IRES, and EGFP reporter gene. (J:341604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1098 strains or lines available

References

• Original: J:341604 Zhao N, et al., Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia. J Exp Med. 2022 Dec 5;219(12)
• All: 2 reference(s)