Prdm16^tm1.1Bjo
Targeted Allele Detail

Summary

• Symbol: Prdm16^tm1.1Bjo
• Name: PR domain containing 16; targeted mutation 1.1, Bryan C Bjork
• MGI ID: MGI:7541323
• Synonyms: Prdm16^cGTinv
• Gene: Prdm16 Location: Chr4:154400582-154721330 bp, - strand Genetic Position: Chr4, 83.96 cM, cytoband E2
• Alliance: Prdm16^tm1.1Bjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242985
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: The conditional gene trap vector FlipROSABgeo* was inserted into intro 2 via homologous recombination. The vector consists of a splice acceptor site, Bgeo* cassette and poly A tail and is flanked by FRT, F3, loxP and lox5171 sites oriented to allow for inversion of the vector. Flp mediated recombination inverted the gene trap vector restoring expression of Prdm16 and preventing expression of the Bgeo reporter. (J:242985)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm16 Mutation: 71 strains or lines available

References

• Original: J:242985 Strassman A, et al., Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping. Dis Model Mech. 2017 Jul 01;10(7):909-922
• All: 2 reference(s)