Patl2^em2Lwa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Patl2^em2Lwa
• Name: protein associated with topoisomerase II homolog 2 (yeast); endonuclease-mediated mutation 2, Lei Wang
• MGI ID: MGI:7541276
• Synonyms: Patl2^-
• Gene: Patl2 Location: Chr2:121950589-122016670 bp, - strand Genetic Position: Chr2, 60.53 cM, cytoband F1
• Alliance: Patl2^em2Lwa page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An 11 bp deletion (TGCCTTCCAAC) was created in exon 1 using an sgRNA with CRISPR/Cas9 technology, leading to a frameshift and premature stop codon (p.A29Gfs*7). (J:338979)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Patl2 Mutation: 30 strains or lines available

References

• Original: J:338979 Zhang Z, et al., PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1. Development. 2023 Jun 15;150(12):dev201572
• All: 1 reference(s)