Patl2^em1Lwa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Patl2^em1Lwa
• Name: protein associated with topoisomerase II homolog 2 (yeast); endonuclease-mediated mutation 1, Lei Wang
• MGI ID: MGI:7541275
• Synonyms: Patl2^S279D
• Gene: Patl2 Location: Chr2:121950589-122016670 bp, - strand Genetic Position: Chr2, 60.53 cM, cytoband F1
• Alliance: Patl2^em1Lwa page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Serine codon 279 (AGC) in exon 11 was changed to aspartic acid (GAT) (p.S279D) using an sgRNA and an ssODN template with CRISPR/Cas9 technology. The mutation prevents phosphorylation of the residue in the encoded peptide. (J:338979)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Patl2 Mutation: 30 strains or lines available

References

• Original: J:338979 Zhang Z, et al., PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1. Development. 2023 Jun 15;150(12):dev201572
• All: 1 reference(s)