Fgf23^tm1.1Wch
Targeted Allele Detail

Summary

• Symbol: Fgf23^tm1.1Wch
• Name: fibroblast growth factor 23; targeted mutation 1.1, Wenhan Chang
• MGI ID: MGI:7541024
• Synonyms: Fgf23^fl
• Gene: Fgf23 Location: Chr6:127049865-127058371 bp, + strand Genetic Position: Chr6, 61.92 cM
• Alliance: Fgf23^tm1.1Wch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297941
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked by loxP sites. An FRT-flanked neomycin cassette was inserted immediately at the 5 end of the second loxP site and a thymidine kinase cassette at the 3-end of exon 2. The neomycin selection cassette was removed via flp-mediated recombination. (J:297941)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgf23 Mutation: 19 strains or lines available

References

• Original: J:297941 Simic P, et al., Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020 Mar 2;130(3):1513-1526
• All: 3 reference(s)