Rr439^em1Rlb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr439^em1Rlb
• Name: regulatory region 439; endonuclease-mediated mutation 1, Robin Lovell-Badge
• MGI ID: MGI:7540993
• Synonyms: Sox2^{tm1(Guide1/1:SRR2)RLB}
• Gene: Rr439 Location: Chr3:34708174-34708233 bp Genetic Position: Chr3, Syntenic
• Alliance: Rr439^em1Rlb page
• IMPC: Rr439 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted the Sox2 regulatory region located 4kb upstream of the gene. (J:302308)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr439 Mutation: 0 strains or lines available

References

• Original: J:302308 Moncho-Amor V, et al., SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2017115118
• All: 1 reference(s)