Nova2^tm4.1Rbd
Targeted Allele Detail

Summary

• Symbol: Nova2^tm4.1Rbd
• Name: NOVA alternative splicing regulator 2; targeted mutation 4.1, Robert B Darnell
• MGI ID: MGI:7540659
• Synonyms: Nova2-cTag^flox
• Gene: Nova2 Location: Chr7:18659813-18699244 bp, + strand Genetic Position: Chr7, 9.41 cM
• Alliance: Nova2^tm4.1Rbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273745
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector replaced exon 4 and the 3UTR with a loxP site, exon 4, 3UTR, 3x SV40 poly(A) terminator, FRT-flanked neomycin cassette, loxP site, and exon 4 fused to AcGFP. The neomycin selection cassette was removed via flp-mediated recombination. (J:273745)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nova2 Mutation: 12 strains or lines available

References

• Original: J:273745 Saito Y, et al., Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function. Neuron. 2019 Feb 20;101(4):707-720.e5
• All: 1 reference(s)