Trem2^em1Gbu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trem2^em1Gbu
• Name: triggering receptor expressed on myeloid cells 2; endonuclease-mediated mutation 1, Guojun Bu
• MGI ID: MGI:7539739
• Synonyms: Trem2 H157Y
• Gene: Trem2 Location: Chr17:48653429-48659304 bp, + strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Trem2^em1Gbu page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution histidine with tyrosine at position 157 (H157Y). (J:341472)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trem2 Mutation: 65 strains or lines available

References

• Original: J:341472 Qiao W, et al., Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology. Mol Neurodegener. 2023 Jan 31;18(1):8
• All: 1 reference(s)