Fto^em1.1Tasun
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fto^em1.1Tasun
• Name: FTO alpha-ketoglutarate dependent dioxygenase; endonuclease-mediated mutation 1.1, Tao Sun
• MGI ID: MGI:7539720
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^em1.1Tasun page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked PGK-neomycin cassette and second loxP site were inserted downstream of exon 3 via CRISRP/Cas9 technology. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:314515)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 76 strains or lines available

References

• Original: J:314515 Du K, et al., Distinct roles of Fto and Mettl3 in controlling development of the cerebral cortex through transcriptional and translational regulations. Cell Death Dis. 2021 Jul 14;12(7):700
• All: 1 reference(s)