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Ightm4.1Mbu
Targeted Allele Detail
Summary
Symbol: Ightm4.1Mbu
Name: immunoglobulin heavy chain complex; targeted mutation 4.1, Meinrad Busslinger
MGI ID: MGI:7539572
Synonyms: IghPgk1-delta890
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:341427
Parent Cell Line:  A9 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe allele was generated by Cre-mediated deletion of 890kb genomic sequence of the lox71/loxP-flanked Igh region in Ightm4Mbu. The deletion left the Pgk1 promoter-driven blasticidin resistance gene. (J:341427)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  41 strains or lines available
References
Original:  J:341427 Hill L, et al., Enhancers of the PAIR4 regulatory module promote distal V(H) gene recombination at the Igh locus. EMBO J. 2023 Aug 1;42(15):e112741
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory