Bcl11b^tm2.1Itan
Targeted Allele Detail

Summary

• Symbol: Bcl11b^tm2.1Itan
• Name: B cell leukemia/lymphoma 11B; targeted mutation 2.1, Ichiro Taniuchi
• MGI ID: MGI:7539429
• Synonyms: Bcl11b^E2PM
• Gene: Bcl11b Location: Chr12:107876662-107969861 bp, - strand Genetic Position: Chr12, 59.1 cM, cytoband F1
• Alliance: Bcl11b^tm2.1Itan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341395
• Parent Cell Line: M1/M-1 (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Three S residues (S95, S96, and S109) in exon 2 of the Bcl11b gene were replaced with A residue. The neo gene flanked with FRT sites was removed by transient transfection of an expression vector encoding Flp recombinase. (J:341395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11b Mutation: 45 strains or lines available

References

• Original: J:341395 Okuyama K, et al., The Majority of the Serine/Threonine Phosphorylation Sites in Bcl11b Protein Are Dispensable for the Differentiation of T Cells. J Immunol. 2023 Jun 1;210(11):1728-1739
• All: 1 reference(s)