Spint2^tm1.1Hk
Targeted Allele Detail

Summary

• Symbol: Spint2^tm1.1Hk
• Name: serine protease inhibitor, Kunitz type 2; targeted mutation 1.1, Hiroaki Kataoka
• MGI ID: MGI:7539362
• Synonyms: Spint2^fl, Spint2^LoxP
• Gene: Spint2 Location: Chr7:28955748-28981337 bp, - strand Genetic Position: Chr7, 16.94 cM
• Alliance: Spint2^tm1.1Hk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278023
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 6. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exons 2-6 floxed. (J:278023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spint2 Mutation: 16 strains or lines available

References

• Original: J:278023 Kawaguchi M, et al., Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine. Commun Biol. 2019;2:11
• All: 2 reference(s)