App^tm1.1Shn
Targeted Allele Detail

Summary

• Symbol: App^tm1.1Shn
• Name: amyloid beta precursor protein; targeted mutation 1.1, Jie Shen
• MGI ID: MGI:7539358
• Synonyms: fAPP
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm1.1Shn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301375
• Parent Cell Line: MKV6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of promoter and exon 1 and an FRT and loxP flanked neo cassette was inserted downstream of exon 1 via homologous recombination. Flp-mediated recombination removed the neo cassette leaving exon 1 floxed. (J:301375)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 118 strains or lines available

References

• Original: J:301375 Lee SH, et al., APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival. Neuron. 2020 Nov 25;108(4):676-690.e8
• All: 2 reference(s)