Psmb11^{tm1.1(AIRE)Mmat}
Targeted Allele Detail

Summary

• Symbol: Psmb11^{tm1.1(AIRE)Mmat}
• Name: proteasome (prosome, macropain) subunit, beta type, 11; targeted mutation 1.1, Mitsuru Matsumoto
• MGI ID: MGI:7539046
• Synonyms: beta5t-GFP
• Gene: Psmb11 Location: Chr14:54862767-54867013 bp, + strand Genetic Position: Chr14, 27.87 cM
• Alliance: Psmb11^{tm1.1(AIRE)Mmat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341377
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutations: Disruption caused by insertion of vector, Insertion
• Psmb11^{tm1.1(AIRE)Mmat} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AIRE (326)

  Aire	(MGI:1338803)

• Mutation details: A KI cassette containing GFP-IRES-hAIREpolyA/frt-Neor-frt was inserted into exon 1 of the Psmb11 locus to disrupt the coding sequence of beta5t. The Neo cassette was removed by crossing the mice with a transgenic (Tg) line expressing the general delete flippase. (J:341377)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psmb11 Mutation: 11 strains or lines available

References

• Original: J:341377 Morimoto J, et al., Cooperative but Distinct Role of Medullary Thymic Epithelial Cells and Dendritic Cells in the Production of Regulatory T Cells in the Thymus. J Immunol. 2023 Jun 1;210(11):1653-1666
• All: 1 reference(s)