Mbnl1^tm1.1Rdd
Targeted Allele Detail

Summary

• Symbol: Mbnl1^tm1.1Rdd
• Name: muscleblind like splicing regulator 1; targeted mutation 1.1, Sita Reddy
• MGI ID: MGI:7538959
• Synonyms: Mbnl1^deltaE2
• Gene: Mbnl1 Location: Chr3:60380251-60537171 bp, + strand Genetic Position: Chr3, 29.17 cM, cytoband E1
• Alliance: Mbnl1^tm1.1Rdd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250496
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2 via homologous recombination. Cre mediated recombination removed the neo cassette and exon 2. (J:250496)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mbnl1 Mutation: 38 strains or lines available

References

• Original: J:250496 Dixon DM, et al., Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms. Sci Rep. 2015 Mar 12;5:9042
• All: 2 reference(s)