Ank2^tm1.1Csbd
Targeted Allele Detail

Summary

• Symbol: Ank2^tm1.1Csbd
• Name: ankyrin 2, brain; targeted mutation 1, Eunjoon Kim
• MGI ID: MGI:7537121
• Gene: Ank2 Location: Chr3:126715261-127292999 bp, - strand Genetic Position: Chr3, 56.07 cM
• Alliance: Ank2^tm1.1Csbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340358
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to contain (from 5'; to 3') an FRT site, an En2 splice acceptor, an internal ribosome entry site (IRES) fused to an EGFP sequence with a polyadenylation signal, and a floxed cassette containing a neo and a second FRT site all upstream of exon 4. A third loxP was placed downstream of exon 4. The frt-flanked neomycin cassette was removed in the germline via FLP-mediated recombination. (J:340358)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ank2 Mutation: 184 strains or lines available

References

• Original: J:340358 Oh H, et al., Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice. Nat Commun. 2023 Jun 15;14(1):3547
• All: 1 reference(s)