Lrp8^tm1.1Dyh
Targeted Allele Detail

Summary

• Symbol: Lrp8^tm1.1Dyh
• Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 1.1, David Y. Hui
• MGI ID: MGI:7537059
• Synonyms: ApoER2^fl
• Gene: Lrp8 Location: Chr4:107659337-107734037 bp, + strand Genetic Position: Chr4, 50.18 cM, cytoband C7
• Alliance: Lrp8^tm1.1Dyh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263909
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting construct was generated in which exons 1 and 2 was flanked with loxP sites placed 2.6 kb upstream of exon 1 in the 5 UTR and 2.6 kb downstream of exon 2 within intron 2. For selection, a neomycin (Neo) cassette flanked by frt recombination sites was also inserted into intron 2. FLP-mediated recombination in the germline removed the neomycin cassette. (J:263909)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp8 Mutation: 42 strains or lines available

References

• Original: J:263909 Sacharidou A, et al., Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium. Blood. 2018 May 10;131(19):2097-2110
• All: 3 reference(s)