Tg(Prnp-CHCHD2*)U144Jaaw
Transgene Detail

Summary

• Symbol: Tg(Prnp-CHCHD2*)U144Jaaw
• Name: transgene insertion U144, Jung-A A Woo
• MGI ID: MGI:7532878
• Synonyms: CHCHD2-T61I^U144
• Transgene: Tg(Prnp-CHCHD2*)U144Jaaw Location: unknown
• Alliance: Tg(Prnp-CHCHD2*)U144Jaaw page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene insert contains the murine prion protein promoter and FLAG tag sequence in-frame with human CHCHD2 cDNA with a mutation that changes threonine codon 61(ACC) to isoleucine (ATC) (c.182C>T p.T61I). The mutation is found in some autosomal dominant Parkinson's disease (PD) patients. (J:340965)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:340965 Kee TR, et al., Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation. Hum Mol Genet. 2022 Nov 28;31(23):3987-4005
• All: 1 reference(s)