Mtdh^em1Dsar
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mtdh^em1Dsar
• Name: metadherin; endonuclease-mediated mutation 1, Devanand Sarkar
• MGI ID: MGI:7532789
• Synonyms: AEG-1-C75S
• Gene: Mtdh Location: Chr15:34082613-34143683 bp, + strand Genetic Position: Chr15, 13.98 cM, cytoband B3.3
• Alliance: Mtdh^em1Dsar page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/cas9 mediated recombination created a T to A substitution resulting in a Cys to Ser mutation at position 75. (J:339563)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtdh Mutation: 32 strains or lines available

References

• Original: J:339563 Komaniecki G, et al., Astrocyte Elevated Gene-1 Cys75 S-Palmitoylation by ZDHHC6 Regulates Its Biological Activity. Biochemistry. 2023 Jan 17;62(2):543-553
• All: 1 reference(s)