Mettl3^em1Chez
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl3^em1Chez
• Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; endonuclease-mediated mutation 1, Zheng Chen
• MGI ID: MGI:7532765
• Synonyms: Mettl3^flox
• Gene: Mettl3 Location: Chr14:52532298-52542585 bp, - strand Genetic Position: Chr14, 26.88 cM, cytoband C1
• Alliance: Mettl3^em1Chez page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: Using the CRISPR-Cas9 technique, two loxp sites flanking the exon 2 and exon 3 of the Mettl3 gene were inserted. (J:287107)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl3 Mutation: 42 strains or lines available

References

• Original: J:287107 Wang Y, et al., METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice. Nat Commun. 2020 Apr 3;11(1):1648
• All: 2 reference(s)