Acsl4^tm1Wgu
Targeted Allele Detail

Summary

• Symbol: Acsl4^tm1Wgu
• Name: acyl-CoA synthetase long-chain family member 4; targeted mutation 1, Wei Gu
• MGI ID: MGI:7532523
• Synonyms: acsl4^FL
• Gene: Acsl4 Location: ChrX:141100989-141173531 bp, - strand Genetic Position: ChrX, 63.12 cM
• Alliance: Acsl4^tm1Wgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282892
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. (J:282892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acsl4 Mutation: 16 strains or lines available

References

• Original: J:282892 Chu B, et al., ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway. Nat Cell Biol. 2019 May;21(5):579-591
• All: 2 reference(s)