F2rl3^{em1(F2RL3)Raca}
Endonuclease-mediated Allele Detail

Summary

• Symbol: F2rl3^{em1(F2RL3)Raca}
• Name: F2R like thrombin or trypsin receptor 3; endonuclease-mediated mutation 1, Robert A Campbell
• MGI ID: MGI:7531842
• Synonyms: hPAR4 Ala120
• Gene: F2rl3 Location: Chr8:73488508-73490502 bp, + strand Genetic Position: Chr8, 35.08 cM, cytoband B3.3
• Alliance: F2rl3^{em1(F2RL3)Raca} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using CRISPR/Cas9, the mouse F2rl3 gene was excised and replaced with an F2RL3 sequence with rs773902 G (hPAR4Ala). (J:341059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2rl3 Mutation: 20 strains or lines available

References

• Original: J:341059 Denorme F, et al., The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes. J Clin Invest. 2023 Sep 15;133(18)
• All: 1 reference(s)