Daam2^em3Hkle
Endonuclease-mediated Allele Detail

Summary

• Symbol: Daam2^em3Hkle
• Name: dishevelled associated activator of morphogenesis 2; endonuclease-mediated mutation 3, Hyun Kyoung Lee
• MGI ID: MGI:7531840
• Synonyms: Daam2-E
• Gene: Daam2 Location: Chr17:49763050-49871371 bp, - strand Genetic Position: Chr17, 25.5 cM
• Alliance: Daam2^em3Hkle page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Using CRISPR-Cas9 genome editing via homology-directed repair, phospho-mimetic mutation (S704E/T705E) was introduced into the Daam2 gene. (J:341055)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Daam2 Mutation: 50 strains or lines available

References

• Original: J:341055 Wang CY, et al., Daam2 phosphorylation by CK2alpha negatively regulates Wnt activity during white matter development and injury. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2304112120
• All: 1 reference(s)