Parp1^tm1.1Shzh
Targeted Allele Detail

Summary

• Symbol: Parp1^tm1.1Shzh
• Name: poly (ADP-ribose) polymerase family, member 1; targeted mutation 1.1, Shan Zha
• MGI ID: MGI:7531481
• Synonyms: Parp1^A, Parp1^E988A
• Gene: Parp1 Location: Chr1:180396456-180428564 bp, + strand Genetic Position: Chr1, 84.44 cM, cytoband H5
• Alliance: Parp1^tm1.1Shzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340904
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Dominant negative)
• Mutation: Single point mutation
• Mutation details: The targeting construct inserted a FRT neomycin resistance cassette in intron 21 and exon 22 was modified with an A to C point mutation encoding the amino acid substitution of glutamic acid with alanine at position 988 (E988A). Flp-mediated recombination removed the selection cassette. (J:340904)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parp1 Mutation: 68 strains or lines available

References

• Original: J:340904 Shao Z, et al., Inactive PARP1 causes embryonic lethality and genome instability in a dominant-negative manner. Proc Natl Acad Sci U S A. 2023;120(31):e2301972120
• All: 1 reference(s)