Grm2^em1Geh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grm2^em1Geh
• Name: glutamate receptor, metabotropic 2; endonuclease-mediated mutation 1, Gregg Homanics
• MGI ID: MGI:7530802
• Synonyms: Grm2^f
• Gene: Grm2 Location: Chr9:106521733-106533308 bp, - strand Genetic Position: Chr9, 57.98 cM
• Alliance: Grm2^em1Geh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 endonuclease-mediated genome editing is used to insert loxP sites in introns 2 and 3. Grm2 transcript Grm2-201 (ENSMUST00000023959.13) was used as reference for the exon number and guide sequences. (J:340723)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grm2 Mutation: 44 strains or lines available

References

• Original: J:340723 Chang DS, et al., Assessment of behavioral flexibility in mice with conditional deletion of metabotropic glutamate receptor 2 from Emx1-lineage neurons. bioRxiv. 2023
• All: 1 reference(s)