Oprm1^em1(cre)Jabl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Oprm1^em1(cre)Jabl
• Name: opioid receptor, mu 1; endonuclease-mediated mutation 1, Julie A Blendy
• MGI ID: MGI:7529797
• Synonyms: Oprm1-Cre
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^em1(cre)Jabl page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Oprm1^em1(cre)Jabl expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Oprm1 (MGI:97441)

• Mutation details: Using CRISPR-Cas9 technology, a T2A cleavable peptide and Cre recombinase was inserted downstream of the last exon (exon 4) in the Oprm1 gene. (J:340529)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Oprm1 (mouse) Summary of all recombinase alleles driven by Oprm1. Alliance mouse Oprm1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 53 strains or lines available

References

• Original: J:340529 Mengaziol J, et al., A novel Oprm1-Cre mouse maintains endogenous expression, function and enables detailed molecular characterization of mu-opioid receptor cells. PLoS One. 2022;17(12):e0270317
• All: 2 reference(s)