Phf6^tm1.1Xmwg
Targeted Allele Detail

Summary

• Symbol: Phf6^tm1.1Xmwg
• Name: PHD finger protein 6; targeted mutation 1.1, Xiaomin Wang
• MGI ID: MGI:7529674
• Synonyms: Phf6^Exon4/5-flox, Phf6^fl
• Gene: Phf6 Location: ChrX:52001143-52045820 bp, + strand Genetic Position: ChrX, 29.28 cM, cytoband A4
• Alliance: Phf6^tm1.1Xmwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320936
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and a loxP site and FRT-flanked neomycin selection cassette were inserted downstream of exon 5. The neomycin selection cassette was removed via flp-mediated recombination, leaving exons 4-5 floxed. (J:320936)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phf6 Mutation: 12 strains or lines available

References

• Original: J:320936 Yuan S, et al., PHF6 and JAK3 mutations cooperate to drive T-cell acute lymphoblastic leukemia progression. Leukemia. 2022 Feb;36(2):370-382
• All: 2 reference(s)