Pten^tm1.1Nrl
Targeted Allele Detail

Summary

• Symbol: Pten^tm1.1Nrl
• Name: phosphatase and tensin homolog; targeted mutation 1.1, Nick R Leslie
• MGI ID: MGI:7529114
• Synonyms: Pten^Y138L
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1.1Nrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330701
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Tyrosine codon 138 (TAT) in exon 5 was changed to leucine (TTG) (p.Y138L) and an FRT site flanked puromycin resistance gene cassette was inserted into intron 4. The puro cassette was removed through subsequent Flp-mediated recombination. The mutation leads to the encoded protein lacking protein phosphatase activity while leaving lipid phosphatase activity intact. (J:330701)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 86 strains or lines available

References

• Original: J:330701 Wise HM, et al., PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate. Biomolecules. 2022 Oct 19;12(10)
• All: 1 reference(s)