Hdac3^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Hdac3^{tm1c(EUCOMM)Wtsi}
• Name: histone deacetylase 3; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7526533
• Synonyms: Hdac3^f
• Gene: Hdac3 Location: Chr18:38070024-38088073 bp, - strand Genetic Position: Chr18, 19.81 cM, cytoband B3
• Alliance: Hdac3^{tm1c(EUCOMM)Wtsi} page
• IMPC: Hdac3 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306873
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 38085175 of Chromosome 18 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 38086156. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:306873)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac3 Mutation: 32 strains or lines available

References

• Original: J:306873 Li L, et al., Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells. iScience. 2019 Oct 25;20:148-167
• All: 2 reference(s)