Pdcd1^tm1.1Rpa
Targeted Allele Detail

Summary

• Symbol: Pdcd1^tm1.1Rpa
• Name: programmed cell death 1; targeted mutation 1.1, Richard D Palmiter
• MGI ID: MGI:7526523
• Synonyms: Pdcd1^fl
• Gene: Pdcd1 Location: Chr1:93966027-93980278 bp, - strand Genetic Position: Chr1, 47.47 cM
• Alliance: Pdcd1^tm1.1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339958
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct was designed to insert LoxP sites that were engineered to flank to second exon of the Pdcd1 gene. FLP recombinase removed the frt-flanked neo cassette. (J:339958)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1 Mutation: 48 strains or lines available

References

• Original: J:339958 Zhao J, et al., PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior. Neuron. 2023 Sep 6;111(17):2709-2726.e9
• All: 1 reference(s)