Gt(ROSA)26Sor^{tm1(tetO-MFSD2A)Dls}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(tetO-MFSD2A)Dls}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David L Silver
• MGI ID: MGI:7525748
• Synonyms: iMfsd2a
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(tetO-MFSD2A)Dls} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340045
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Inserted expressed sequence, Transactivator)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(tetO-MFSD2A)Dls} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MFSD2A (84879)

  Mfsd2a

  (MGI:1923824)

• Gt(ROSA)26Sor^{tm1(tetO-MFSD2A)Dls} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  bacteria	tetO

• Mutation details: Through homologous recombination, the human MSFD2A cDNA was inserted into the Rosa26 locus under the control of rtTA (reverse tetracycline-controlled transactivator). rtTA transcription is prevented with a stop codon, flanked by loxP sites. (J:340045)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:340045 Loke RYJ, et al., Mfsd2a-mediated lysolipid transport is important for renal recovery after acute kidney injury. J Lipid Res. 2023 Jul 17;64(8):100416
• All: 2 reference(s)