Sigmar1^em1Gan
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sigmar1^em1Gan
• Name: sigma non-opioid intracellular receptor 1; endonuclease-mediated mutation 1, Lin Gan
• MGI ID: MGI:7525746
• Synonyms: Sigmar1^loxP
• Gene: Sigmar1 Location: Chr4:41738493-41741359 bp, - strand Genetic Position: Chr4, 22.05 cM, cytoband A5-B2
• Alliance: Sigmar1^em1Gan page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology inserted loxP sites in the 5 UTR and 3 UTR of the gene, generating an exon 1-4 floxed allele. (J:340040)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sigmar1 Mutation: 22 strains or lines available

References

• Original: J:340040 Huang L, et al., Generation of Sigmar1 conditional knockout mouse using CRISPR-Cas9 gene targeting. Genesis. 2022 Jul;60(6-7):e23487
• All: 1 reference(s)