Cd27^tm1.1Ivo
Targeted Allele Detail

Summary

• Symbol: Cd27^tm1.1Ivo
• Name: CD27 antigen; targeted mutation 1.1, Isabel Vogel
• MGI ID: MGI:7525735
• Synonyms: CD27^flox
• Gene: Cd27 Location: Chr6:125209585-125213973 bp, - strand Genetic Position: Chr6, 59.32 cM
• Alliance: Cd27^tm1.1Ivo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340035
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT-flanked PGK-neomycin cassette and second loxP site were inserted downstream of exon 2. The selection cassette was removed via flp-mediated recombination, leaving exons 1-2 floxed. (J:340035)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd27 Mutation: 25 strains or lines available

References

• Original: J:340035 Vogel I, et al., Agonistic anti-CD27 antibody ameliorates EAE by suppressing IL-17 production. Eur J Immunol. 2022 Jul 20
• All: 1 reference(s)