Pld2^tm1.2Wz
Targeted Allele Detail

Summary

• Symbol: Pld2^tm1.2Wz
• Name: phospholipase D2; targeted mutation 1.2, Weiguo Zhang
• MGI ID: MGI:7525726
• Synonyms: Pld2^-
• Gene: Pld2 Location: Chr11:70430890-70448936 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Pld2^tm1.2Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260679
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct was designed to insert a loxP site in the intron upstream of Exon11 and FRT-flanked neo cassette followed by another loxP site into the intron downstream of Exon 12 of the Pld2 gene. Flp mediated recombination removed the neo cassette. Cre-mediated recombination excised the exons 11 and 12. (J:260679)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pld2 Mutation: 47 strains or lines available

References

• Original: J:260679 Zhu M, et al., Differential Roles of Phospholipase D Proteins in FcepsilonRI-Mediated Signaling and Mast Cell Function. J Immunol. 2015 Nov 1;195(9):4492-502
• All: 2 reference(s)