Pld1^tm1.1Wz
Targeted Allele Detail

Summary

• Symbol: Pld1^tm1.1Wz
• Name: phospholipase D1; targeted mutation 1.1, Weiguo Zhang
• MGI ID: MGI:7525720
• Gene: Pld1 Location: Chr3:27992844-28187511 bp, + strand Genetic Position: Chr3, 11.15 cM
• Alliance: Pld1^tm1.1Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260679
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct was designed to insert a loxP site in the intron upstream of Exon11 and FRT-flanked neo cassette followed by another loxP site into the intron downstream of Exon 11 of the Pld1 gene. Flp mediated recombination removed the neo cassette leaving the exon 11 floxed. (J:260679)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pld1 Mutation: 64 strains or lines available

References

• Original: J:260679 Zhu M, et al., Differential Roles of Phospholipase D Proteins in FcepsilonRI-Mediated Signaling and Mast Cell Function. J Immunol. 2015 Nov 1;195(9):4492-502
• All: 1 reference(s)