Amelx^tm1.1Hcma
Targeted Allele Detail

Summary

• Symbol: Amelx^tm1.1Hcma
• Name: amelogenin, X-linked; targeted mutation 1.1, Henry C Margolis
• MGI ID: MGI:7525652
• Synonyms: AMELX-S16A KI
• Gene: Amelx Location: ChrX:167959110-167970196 bp, - strand Genetic Position: ChrX, 78.95 cM
• Alliance: Amelx^tm1.1Hcma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340005
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector introduced a point mutation (Ser-16 to Ala-16: AGC>>GCC; S16A) on exon 3 in the X-chromosomal Amelx gene. The FRT-flanked neomycin selection cassette was removed by Flp recombinase. (J:340005)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amelx Mutation: 25 strains or lines available

References

• Original: J:340005 Stifler CA, et al., Loss of biological control of enamel mineralization in amelogenin-phosphorylation-deficient mice. J Struct Biol. 2022 Jun;214(2):107844
• All: 1 reference(s)