Srebf1^{tm1(SREBF1)Cgd}
Targeted Allele Detail

Summary

• Symbol: Srebf1^{tm1(SREBF1)Cgd}
• Name: sterol regulatory element binding transcription factor 1; targeted mutation 1, Carlos G Dotti
• MGI ID: MGI:7525333
• Synonyms: miR-33bKI
• Gene: Srebf1 Location: Chr11:60089915-60113407 bp, - strand Genetic Position: Chr11, 37.81 cM
• Alliance: Srebf1^{tm1(SREBF1)Cgd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:338781
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Srebf1^{tm1(SREBF1)Cgd} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MIR33B (693120)

  human

  SREBF1 (6720)

  Srebf1

  (MGI:107606)

• Mutation details: The entire mouse Srebp1 gene was removed and replaced with the human sequence, including the human SREBF1 gene and the region encoding the human MIR33B miroRNA gene within the intron. (J:338781)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srebf1 Mutation: 55 strains or lines available

References

• Original: J:338781 Guix FX, et al., Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup. Life Sci Alliance. 2021 Aug;4(8)
• All: 1 reference(s)