Ang^tm1.1Gfhu
Targeted Allele Detail

Summary

• Symbol: Ang^tm1.1Gfhu
• Name: angiogenin, ribonuclease, RNase A family, 5; targeted mutation 1.1, Guo-fu Hu
• MGI ID: MGI:7525281
• Synonyms: Ang1^-
• Gene: Ang Location: Chr14:51328607-51339462 bp, + strand Genetic Position: Chr14, 26.37 cM, cytoband B-C1
• Alliance: Ang^tm1.1Gfhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339254
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A pGK-gb2 loxP/FRT-flanked Neomycin cassette was inserted 161 nt upstream from the coding exon 2, and an additional loxP site was inserted 80 nt downstream from the coding exon. Mice were crossed with EIIa-Cre mice to remove the loxP flanked coding sequence in the germline. (J:339254)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ang Mutation: 15 strains or lines available

References

• Original: J:339254 Yang H, et al., Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival. Br J Cancer. 2022 Aug;127(3):422-435
• All: 1 reference(s)