Kdm5b^em1Zhanz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kdm5b^em1Zhanz
• Name: lysine demethylase 5B; endonuclease-mediated mutation 1, Zhenzhen Zhan
• MGI ID: MGI:7524555
• Gene: Kdm5b Location: Chr1:134487916-134560621 bp, + strand Genetic Position: Chr1, 58.24 cM, cytoband E4
• Alliance: Kdm5b^em1Zhanz page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 428 bp deletion containing the JmjC domain, which is responsible for its demethylase activity, resulting in a frameshift and loss of function. (J:339844)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm5b Mutation: 198 strains or lines available

References

• Original: J:339844 Wang B, et al., Loss of KDM5B ameliorates pathological cardiac fibrosis and dysfunction by epigenetically enhancing ATF3 expression. Exp Mol Med. 2022 Dec;54(12):2175-2187
• All: 1 reference(s)