Prlhr^em1Smln
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prlhr^em1Smln
• Name: prolactin releasing hormone receptor; endonuclease-mediated mutation 1, Simon M Luckman
• MGI ID: MGI:7524438
• Synonyms: Gpr10^P193S
• Gene: Prlhr Location: Chr19:60455170-60456742 bp, - strand Genetic Position: Chr19, 56.52 cM
• Alliance: Prlhr^em1Smln page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: CRISRP/Cas9 technology generated CCG to TCG change resulting in a proline to serine substitution at amino acid 193 (p.P193S). A second silent C to T mutation was also introduced to cause a loss of an Eagl restriction site for screening. The p.P193S is a rare loss of function variant identified in an individual with severe obesity. (J:339803)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prlhr Mutation: 17 strains or lines available

References

• Original: J:339803 Talbot F, et al., A rare human variant that disrupts GPR10 signalling causes weight gain in mice. Nat Commun. 2023 Mar 15;14(1):1450
• All: 1 reference(s)