Gt(ROSA)26Sor^{em1(CAG-ERBB2*V777L)Bose}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-ERBB2*V777L)Bose}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Ron Bose
• MGI ID: MGI:7524181
• Synonyms: HER2^V777L
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-ERBB2*V777L)Bose} page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-ERBB2*V777L)Bose} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERBB2 (2064)

  Erbb2

  (MGI:95410)

  Contains p.V777L mutation found in colorectal cancer

• Mutation details: TALEN technology inserted a CAG promoter, loxP-flanked STOP, and ERBB2 containing a valine to leucine substitution at amino acid 777 into the locus. The p.V777L mutation is a constitutively activated mutation identified in human colorectal cancer patients. (J:314240)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:314240 Murray E, et al., HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium. Cell Mol Gastroenterol Hepatol. 2021;12(3):1105-1120
• All: 2 reference(s)