Ifih1^em2Ygch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ifih1^em2Ygch
• Name: interferon induced with helicase C domain 1; endonuclease-mediated mutation 2, Yi-Guang Chen
• MGI ID: MGI:7523925
• Synonyms: Ifih1^deltaHel1
• Gene: Ifih1 Location: Chr2:62426142-62476599 bp, - strand Genetic Position: Chr2, 35.85 cM, cytoband C3
• Alliance: Ifih1^em2Ygch page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: Zinc finger nuclease-mediated genome editing targets exon 6, creating an in-frame 15bp deletion (AA 428-432). (J:339647)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ifih1 Mutation: 43 strains or lines available

References

• Original: J:339647 Blum SI, et al., MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance. JCI Insight. 2023 Jan 24;8(2)
• All: 1 reference(s)