Bbx^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Bbx^{tm1d(EUCOMM)Wtsi}
• Name: bobby sox HMG box containing; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:7523300
• Synonyms: Bbx^-
• Gene: Bbx Location: Chr16:50012207-50252753 bp, - strand Genetic Position: Chr16, 31.35 cM
• Alliance: Bbx^{tm1d(EUCOMM)Wtsi} page
• IMPC: Bbx gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339059
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_gt0 cassette was inserted at position 50086263 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 50087177. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:339059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bbx Mutation: 90 strains or lines available

References

• Original: J:339059 Ihn HJ, et al., Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. J Cell Physiol. 2021 Jan;236(1):480-488
• All: 2 reference(s)