Bbx^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Bbx^{tm1c(EUCOMM)Wtsi}
• Name: bobby sox HMG box containing; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7523299
• Synonyms: Bbx^fl
• Gene: Bbx Location: Chr16:50012207-50252753 bp, - strand Genetic Position: Chr16, 31.35 cM
• Alliance: Bbx^{tm1c(EUCOMM)Wtsi} page
• IMPC: Bbx gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339059
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 50086263 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 50087177. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:339059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bbx Mutation: 90 strains or lines available

References

• Original: J:339059 Ihn HJ, et al., Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. J Cell Physiol. 2021 Jan;236(1):480-488
• All: 2 reference(s)