Cnksr2^tm1.1Ssod
Targeted Allele Detail

Summary

• Symbol: Cnksr2^tm1.1Ssod
• Name: connector enhancer of kinase suppressor of Ras 2; targeted mutation 1.1, Scott H Soderling
• MGI ID: MGI:7523257
• Gene: Cnksr2 Location: ChrX:156604432-156826290 bp, - strand Genetic Position: ChrX, 72.76 cM
• Alliance: Cnksr2^tm1.1Ssod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339544
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 2. The selection cassette was removed via flp-mediated recombination, leaving exon 2 floxed. Deleting exon 2 preserves the native start codon and abolishes both isoforms of Cnksr2. (J:101977, J:339544)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cnksr2 Mutation: 11 strains or lines available

References

• Original: J:339544 Erata E, et al., Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome. J Neurosci. 2021 Nov 17;41(46):9633-9649
• All: 3 reference(s)