Cdk2^tm2.2Sgo
Targeted Allele Detail

Summary

• Symbol: Cdk2^tm2.2Sgo
• Name: cyclin dependent kinase 2; targeted mutation 2.2, Sagrario Ortega
• MGI ID: MGI:7522404
• Synonyms: CDK2 KO
• Gene: Cdk2 Location: Chr10:128533808-128540900 bp, - strand Genetic Position: Chr10, 77.13 cM, cytoband D3
• Alliance: Cdk2^tm2.2Sgo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339388
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance gene flanked by loxP sites was inserted into intron 3 while a third loxP site was inserted into intron 1. Insertion was confirmed by Southern blot analysis. Cre-mediated recombination in the germline resulted in the deletion of exons 2 and 3 and the neomycin resistance gene. (J:339388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk2 Mutation: 16 strains or lines available

References

• Original: J:339388 Teitz T, et al., CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss. J Exp Med. 2018 Apr 2;215(4):1187-1203
• All: 2 reference(s)