Arx^tm1.1Gldn
Targeted Allele Detail

Summary

• Symbol: Arx^tm1.1Gldn
• Name: aristaless related homeobox; targeted mutation 1.1, Jeffrey A Golden
• MGI ID: MGI:7522369
• Gene: Arx Location: ChrX:92330113-92341963 bp, + strand Genetic Position: ChrX, 41.05 cM
• Alliance: Arx^tm1.1Gldn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306019
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon2 of the Arx gene was flanked by loxP and frt-neoR-frt-loxP sites. The neomycin selection cassette and exon 2 were removed in the germline via FLP and Cre-mediated recombination. (J:306019)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arx Mutation: 20 strains or lines available

References

• Original: J:306019 Sunnen CN, et al., Arx is required for specification of the zona incerta and reticular nucleus of the thalamus. J Neuropathol Exp Neurol. 2014 Mar;73(3):253-61
• All: 1 reference(s)