Msh2^tm3Htr
Targeted Allele Detail

Summary

• Symbol: Msh2^tm3Htr
• Name: mutS homolog 2; targeted mutation 3, Hein Te Riele
• MGI ID: MGI:7522368
• Synonyms: Msh2^lox
• Gene: Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh2^tm3Htr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339064
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted 53 bp downstream of exon 13 and a floxed neomycin gene driven by the MC1 promoter was inserted 2 kb upstream of exon 12 with both loxP sites in the opposite orientation of the single loxP site. (J:339372)

Tumor Data

List all tumor models in MMHCdb carrying Msh2^tm3Htr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msh2 Mutation: 95 strains or lines available

Notes

ES cell = Msh2-55 (generated from E14 ES cells targeted for Msh2^tm1Htr (MGI:1858055).

References

• Original: J:339064 Wojciechowicz K, et al., Temozolomide increases the number of mismatch repair-deficient intestinal crypts and accelerates tumorigenesis in a mouse model of Lynch syndrome. Gastroenterology. 2014 Nov;147(5):1064-72.e5
• All: 2 reference(s)